A University College of London Vice-Provost and clinical academic lays out scenarios.
I worry we're not worried enough about Scenario 4.
There are four likely scenarios for exiting this pandemic:
- Development of a vaccine. A vaccine that successfully blocks transmission would be the most ideal strategy. Over 170 companies are now developing vaccines with three in large scale, clinical trials. It is essential that vaccines show not only an immune response (which they all do) but that this is sufficient to protect against severe disease and against transmission of the virus. There are, however, concerns that any protection may not break the transmission cycle and that immunity will be transient, as is the case for natural immunity of people, infected with coronavirus. A new vaccine typically takes four years to develop. It is my view that a vaccine is unlikely to be successfully developed that leads us to exit the current crisis. The other concern is the recent report of the infection of an individual, who had already had coronavirus. Re-infection was with a mutated strain and this suggests that vaccines will need to deal with natural variation or target the invariable part of the virus.
- The SARS-CoV2 naturally loses infectivity, as may well have occurred during the Spanish influenza outbreak in 1918-20. However, coronaviruses do not mutate at the same rate as the influenza virus.
- We develop herd immunity: an R0 of 2.6 means that approx. 62% of the population would need to be immune, at any one time, in order to develop herd immunity. Herd immunity values are currently approximately 0.5-15% in different areas of the country. Any recurrent waves of infection will be required to acquire a 62% target and that would assume that immunity is long lasting, rather than transient.
- The virus becomes endemic: this would mean the virus circulating in the community with intermittent flare ups that are handled by local lockdowns and standard NHS treatment. Interpretation of the current data is that case numbers are going up but there are no significant numbers of admissions to hospitals, at least in London. This likely reflects the testing of younger, more mobile people who do not succumb to the symptoms of coronavirus whereas, in the past, the people, who were tested, were those who had been admitted to hospital.
Thinking hard about the worst case makes all options look worse.
But before that - some cause for optimism. A vaccine may be more likely than scenario 1 suggests. Saloni Dattani reviews the evidence and the forecasts here.
But let's go with a worst-case where either a vaccine isn't successful, or where vaccines need boosters so frequently and where new strains requiring new vaccines keep emerging, so even 100% vaccination implies new outbreaks in the absence of tight border controls against the entry of new strains.
The rest of the world is not following an elimination strategy. The longer this goes, the less likely it seems that they will even try. Too many places haven't the political cohesion to pull it off, even if they wanted to.
Whatever you think about Sweden, they aren't going to hit herd immunity in Scenario 4. Herd immunity doesn't exist. It's just recurring Covid seasons, just like the common cold, except it kills a lot of people and leaves a lot of people with long term disability.
If you want to run this direction, expect to spend a pile of money increasing capacity in hospitals and ICUs. Disability benefits will go up as reduced lung capacity prevents employment; spending on retraining would have to go up to enable shifts into other sectors. There would, in NZ, be pressure to shift ACC to cover this kind of harm, and making ACC cover health more generally rather than just accidents would probably break it.
Expect contraction in hospitality and similar sectors as those who are risk averse take their own measures to reduce risk - at least until self-testing becomes ubiquitous. Look at the app integration of the latest Abbott test, which will show your latest test result. That test doesn't get us all the way there yet because it isn't an at-home test. We will get to at-home tests that are reliable enough while people are infectious, and cheap enough that they can be used daily or close to it. Restaurants and bars that want customers will require a recent test result as condition of entry. Risker workplaces, where distancing is harder, will test staff frequently to avoid on-site outbreaks that stymie production. When tests cost about as much as a cup of fancy coffee, workplaces will just do it. We will all be poorer by the real resources consumed in that regular testing, as compared to the pre-Covid counterfactual, but it's better than not-testing.
There will still be recurring waves of illness, with consequent loss of life and morbidity, because even with lots of cheap tests around, some folks you just can't reach short of compulsory measures. Unless the schools are willing to enforce a regular testing regimen and to exclude students while infectious, it would at minimum come through that route. Even if each test isn't that expensive, testing each kid regularly would add an awful lot to school operating costs. School budgets would have to go up to accommodate it.
Expect also that aged care facilities will be under heavy restrictions for the foreseeable future, with strict testing requirements for entry.
None of that sounds good.
But neither do any of the other options. The other options may be less bad. But all options are bad. Everything sucks in Scenario 4. What sucks least isn't obvious.
New Zealand and a small set of East Asian countries could hold to a strict elimination strategy, defend the borders, have robust systems for monitoring and trusting each other, and free mobility within the Green Zone. Advances in testing and compromises on some civil liberties for those entering the Green Zone, including rigorous testing and check-in requirements. Periods in managed isolation (NZ) or monitored and enforced self-isolation (Taiwan) can be shortened if it's possible to track people as they leave isolation and require them to self-test regularly. That increases throughput at the border without increasing risk.
But the border will remain a horrible and costly bottleneck. I don't just mean monetary costs, obviously. There are huge humanitarian problems in imposing massive costs on travel. Remember isochronic maps? The maps that showed all the places you could get to, from London, in the same amount of time?
We wouldn't be going all the way back to 1914, when most of New Zealand was 30-40 days from London. But coming into NZ from anywhere outside of a green zone would be a day's travel plus, at best, a week in self-isolation.
Here's 1914 as reminder:
- A more risk-responsive set of isolation requirements, combined with options for self-isolation.
- People coming from places outside of the Green Zone where COVID is less prevalent could have shorter isolation periods, if other risk-management protocols were put in place like post-isolation testing and location tracking. Halving the duration of isolation doubles effective capacity.
- People willing to wear location monitoring bracelets could be allowed to isolate at home, if that home were a safe place for self-isolation - not having other flatmates, for example. I have no doubt that the American Ambassador's self-isolation in his home will be safe, and that his being there instead of in a managed isolation facility frees up a space in managed isolation for someone else. But figuring out a regime to work it all won't be easy. It requires checking that the proposed venue doesn't have others who'd be mingling. It isn't crazy to think that the costs of vetting a venue could be a reasonable fraction of the cost of providing a room in managed isolation. And while putting a monitoring bracelet on people is relatively easy in principle, keeping others from popping round for a visit is harder. The default could be managed isolation unless the traveller can demonstrate a credible self-isolation plan, but all of that will prove hard. There will be muppets who decide to have a party while they're self-isolating, and unless there are good chances of being caught and penalised for doing so, it'll be hard to deter.
- The whole voucher system I'd suggested to allow more facilities to come into the MIQ system - but it is still really costly both in resource and time, even if a lot of people are contributing to the costs of their own stays.
Some big news out of the University of Arizona (@uarizona):
— (((Charles Fishman))) (@cfishman) August 27, 2020
UA scientists & staff found a coronavirus outbreak on campus *before it happened* — and seem to have snuffed it out.
How in the world do you do that?
You use wastewater testing.